CD41, CD61 Antikörper

Produktnummer ABIN2664684

Dieser Maus Monoklonal Antikörper erkennt spezifisch CD41, CD61 in FACS. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für CD41, CD61 Antikörper (ABIN2664684)

Target: CD41, CD61 (CD41,CD61)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD41, CD61 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Klon: PAC-1

Produktdetails anti-CD41, CD61 Antikörper

Aufreinigung: The antibody was purified by affinity chromatography.

Isotyp: IgM kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Details zu CD41, CD61

Target: CD41, CD61 (CD41,CD61)

Andere Bezeichnung: CD41/CD61

Hintergrund: The gpIIb/IIIa complex, also known as integrin αIIbβ3, is expressed by megakaryocytes and platelets. It undergoes conformational changes upon activation by substances, such as ADP, thrombin, and TXA2, which subsequently reveals a ligand binding site that is specific for fibrinogen, von Willebrand factor (vWF), fibronectin, and vitronectin. This conformational change is crucial for platelet-platelet adhesion. Ligand bound gpIIb/IIIa complex promotes platelet aggregation. This complex plays an important role in hemostasis and is a target for developing therapeutic antibodies in immune thrombocytopenia.